This briefing note provides guidance to colleagues in the European Commission's Directorate-General for International Partnerships (INTPA) and EU delegations on designing digital initiatives that promote gender equality and empower women and girls. It outlines a reciprocal approach: mainstreaming gender in digitalisation policies and measures while leveraging digitalisation to advance gender equality and women’s rights across key areas highlighted in GAP III. Additionally, it aids in identifying focus areas for gender sector analysis to formulate digital programmes that transform gender-power relations for positive economic, social, and cultural change.